Leonor Saiz

Leonor Saiz

Position Title
Associate Professor

  • Biomedical Engineering
1115 Academic Surge
Bio
Systems therapeutics, computational biomedicine, biological networks, biomolecular systems, bioinformatics 

Dr. Saiz’s Modeling of Biological Networks and Systems Theraputics Laboratory develops and applies computational approaches to characterize the properties of protein-protein and protein-DNA complexes and their effects on cellular processes. Her lab’s current projects include studying molecular dynamics on the atomic scale and applying network methods to investigate mammalian gene regulation and signal transduction. Her laboratory is also developing computational methods and tools to guide the development of targeted therapies. The team has already successfully applied them to identify potential therapeutic targets in the TGF-β pathway for mutations of the pathway components in human cancer.

Accepting students per funding availability.

Research Interests & Expertise
  • Computational and theoretical approaches to the study of biological networks at the cellular and molecular level
  • Multiscale and multilevel approaches to study biomolecular processes
  • Assembly of macromolecular complexes on DNA, membranes, and scaffols
  • Statistical mechanics basis of gene regulation and signal transduction
  • Noise in cellular processes
  • In vivo biomolecular mechanics
  • Molecular biophysics: membranes, membrane associated proteins, and their interactions with small molecules and drugs

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